Francine Joy "Fran" Fine-Sheffield "born November,26,1964" was born the second daughter of Sylvia Fine and Morty Fine. Fran was raised in Flushing, Queens in New York city beside her sister Nadine.Fran and best friend Valerie Toriello attended local Hillcrest High School alongside fellow students Ray Barone, Fran's arch-rival, Heather Biblow, the late actress, Morgan Faulkner, and taxicab driver wannabe playwright Jeffrey Needlemen.
Upon graduating, Fran attended cosmetics college while working as a foot model. She later assisted in her then-fiancé Danny Imperiali in his bridal shop in Flushing, Queens until she was dumped by Imperiali who immediately replaced her with Heather Biblow. Not only did Heather steal Fran's job, she also married Danny instead.
Fran decides to do a little investigation on the man her mother is seeing, and discovers him to be a lovely man. Sylvia finds out she was at the doctor's office and breaks up with Fran. Fran then decides to give her father a few hints for pleasing Sylvia and turn their boring marriage around. The two couples go out for dinner, and Morty runs into Dr. Razzo in the men's room. Fran tries to talk her father into not giving up on Sylvia, and Dr. Razzo supports her. Morty goes back to the table and sings a romantic song for his wife, solving once and for all their marital conflicts.
Meanwhile, Niles makes his stage debut on Gracie's school play and makes a fool of himself.